Jessica Santana is one of the co-founders of New York On Tech (NYOT), a 501c3 nonprofit organization on a mission to prepare the next generation of technology leaders emerging from New York City. NYOT provides underrepresented students with access to the development, mentoring, networking and professional experiences that prepare them for degrees and careers in technology. Their work has been featured in major media outlets such as Forbes, CNN, Wells Fargo, Sirius XM Radio, Huffington Post, TechCrunch, BET, Black Enterprise, AlleyWatch and The Network Journal.

Prior to NYOT, Santana worked as a technology consultant for global brands such as JPMorgan Chase, Accenture and Deloitte and has been named to the Forbes 30 Under 30 list. She is a Ashoka Emerging Innovator, Pahara Institute Next-Gen Leader, World Economic Forum Global Shaper, Entrepreneur in Residence at General Assembly, 2015 Wells Fargo Millennial Activist, 2015 Camelback Ventures Social Innovation Fellow, 2016 Points of Light Civic Accelerator Entrepreneur, 4.0 Schools Launch Entrepreneur, JPMorganChase Global Enterprise Technology Leader, Morgan Stanley Emerging Leader, Deloitte Future Leaders Apprentice​ and one of 50 Visionary Women L​eaders to Watch in 2015 by Innov8t​iv Magazine. Santana is also one of the inaugural technology anchors on Univision.

Her commitment to philanthropy and community engagement is evidenced by her world travels and work in parts of Europe, China and South America to work with nonprofits, private companies and social enterprises that better local communities and economies. She graduated with degrees in Accounting and Information Technology from Syracuse University.